Proteogenomic characterization was performed in 262 intrahepatic cholangiocarcinoma (iCCA) patients. Aflatoxin signature was associated with tumor initiation, proliferation, and immune suppression. Mutation-associated signaling profiles revealed that TP53 and KRAS co-mutations may contribute to iCCA metastasis via the integrin-FAK-SRC pathway. FGFR2 fusions activated the Rho GTPase pathway and could be a potential source of neoantigens. Four different subclasses were identified with different prognosis, genetic alterations, immune infiltration, tumor microbiota composition, and potential therapeutics.

(Dong, L., et al. – Cancer Cell, January 2022)

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