This monocentric non-inferiority randomized controlled trial has compared proton beam radiotherapy (72 patients) and radiofrequency ablation (72 patients) for the treatment of uni or bifocal HCC of less than 3 cm. Proton beam radiotherapy was non-inferior in term of percentages of local progression-free survival at 2 years compared to radiofrequency ablation. An external multicentric validation of these results are required.

(Tae Hyun Kim et al. – J Hepatol, 5 October 2020)

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