The authors were aimed to investigate the molecular-phenotypic correlations in a large series (n=343) of surgically resected HCC. The authors showed that CTNNB1 (40%) and TP53 (21%) mutations were mutually exclusive and defined two major groups of HCC characterized by distinct phenotypes. CTNNB1 mutated-tumours were large, well-differentiated, cholestastic, with microtrabecular and pseudoglandular patterns and without inflammatory infiltrates. Contrarily, TP53 mutated-tumours were poorly-differentiated with compact pattern, multinucleated and pleomorphic cells and frequent vascular invasion. Also, World Health Organization (WHO) histological subtypes were also strongly related to molecular features.
(Calderaro J et al. – Journal of Hepatology, 19 May 2017)