Establishing hepatocellular carcinoma (HCC) patient-derived xenografts (PDX) has been a challenge, in part due to limitations in procuring samples. In this study, Blumer et al. establish HCC-PDX from needle biopsies. Interestingly, the PDXs maintained the genomic and transcriptomic features of the original tumors over several passages. Establishment of additional PDX models will fuel preclinical HCC research.
(Tanja Blumer et al. – Hepatology Communications, July 2019)